Caspase-11 promotes allergic airway inflammation

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E(2) (PGE(2)) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE(2) suppreses caspase-11 expression in murine and human macrophages and in the...

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Udgivet i:Nat Commun
Main Authors: Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044193/
https://ncbi.nlm.nih.gov/pubmed/32103022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14945-2
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