Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2

Malaria parasites suppress host immune responses to facilitate their survival, but the underlying mechanism remains elusive. Here, we found that blood-stage malaria parasites predominantly induced CD4(+)Foxp3(+)CD25(+) regulatory T cells to release soluble fibrinogen-like protein 2 (sFGL2), which su...

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Udgivet i:Sci Adv
Main Authors: Fu, Yong, Ding, Yan, Wang, Qinghui, Zhu, Feng, Tan, Yulong, Lu, Xiao, Guo, Bo, Zhang, Qingfeng, Cao, Yaming, Liu, Taiping, Cui, Liwang, Xu, Wenyue
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043914/
https://ncbi.nlm.nih.gov/pubmed/32133407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9269
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