Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2

Malaria parasites suppress host immune responses to facilitate their survival, but the underlying mechanism remains elusive. Here, we found that blood-stage malaria parasites predominantly induced CD4(+)Foxp3(+)CD25(+) regulatory T cells to release soluble fibrinogen-like protein 2 (sFGL2), which su...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Fu, Yong, Ding, Yan, Wang, Qinghui, Zhu, Feng, Tan, Yulong, Lu, Xiao, Guo, Bo, Zhang, Qingfeng, Cao, Yaming, Liu, Taiping, Cui, Liwang, Xu, Wenyue
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043914/
https://ncbi.nlm.nih.gov/pubmed/32133407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9269
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