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KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation

Natural killer (NK) cell recognition and killing of target cells are enhanced when inhibitory killer immunoglobulin-like receptors (KIR) are unable to engage their cognate HLA class I ligands. The genes of the KIR locus are organized into either KIR B haplotypes, containing 1 or more activating KIR...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Weisdorf, Daniel, Cooley, Sarah, Wang, Tao, Trachtenberg, Elizabeth, Vierra-Green, Cynthia, Spellman, Stephen, Sees, Jennifer A., Spahn, Ashley, Vogel, Jenny, Fehniger, Todd A., Woolfrey, Ann E., Devine, Steven M., Ross, Maureen, Waller, Edmund K., Sobecks, Ronald M., McGuirk, Joseph, Oran, Betul, Farag, Sherif S., Shore, Tsiporah, Van Besien, Koen, Marsh, Steven G. E., Guethlein, Lisbeth A., Parham, Peter, Miller, Jeffrey S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042994/
https://ncbi.nlm.nih.gov/pubmed/32092137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001053
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