KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation

Natural killer (NK) cell recognition and killing of target cells are enhanced when inhibitory killer immunoglobulin-like receptors (KIR) are unable to engage their cognate HLA class I ligands. The genes of the KIR locus are organized into either KIR B haplotypes, containing 1 or more activating KIR...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Weisdorf, Daniel, Cooley, Sarah, Wang, Tao, Trachtenberg, Elizabeth, Vierra-Green, Cynthia, Spellman, Stephen, Sees, Jennifer A., Spahn, Ashley, Vogel, Jenny, Fehniger, Todd A., Woolfrey, Ann E., Devine, Steven M., Ross, Maureen, Waller, Edmund K., Sobecks, Ronald M., McGuirk, Joseph, Oran, Betul, Farag, Sherif S., Shore, Tsiporah, Van Besien, Koen, Marsh, Steven G. E., Guethlein, Lisbeth A., Parham, Peter, Miller, Jeffrey S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042994/
https://ncbi.nlm.nih.gov/pubmed/32092137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001053
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