KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation

Natural killer (NK) cell recognition and killing of target cells are enhanced when inhibitory killer immunoglobulin-like receptors (KIR) are unable to engage their cognate HLA class I ligands. The genes of the KIR locus are organized into either KIR B haplotypes, containing 1 or more activating KIR...

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Udgivet i:Blood Adv
Main Authors: Weisdorf, Daniel, Cooley, Sarah, Wang, Tao, Trachtenberg, Elizabeth, Vierra-Green, Cynthia, Spellman, Stephen, Sees, Jennifer A., Spahn, Ashley, Vogel, Jenny, Fehniger, Todd A., Woolfrey, Ann E., Devine, Steven M., Ross, Maureen, Waller, Edmund K., Sobecks, Ronald M., McGuirk, Joseph, Oran, Betul, Farag, Sherif S., Shore, Tsiporah, Van Besien, Koen, Marsh, Steven G. E., Guethlein, Lisbeth A., Parham, Peter, Miller, Jeffrey S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042994/
https://ncbi.nlm.nih.gov/pubmed/32092137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001053
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