A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

Common variants of about 20 genes contributing to AD risk have so far been identified through genome-wide association studies (GWAS). However, there is still a large proportion of heritability that might be explained by rare but functionally important variants. One of the so far identified genes wit...

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Publicado no:Mol Psychiatry
Main Authors: Hartl, Daniela, May, Patrick, Gu, Wei, Mayhaus, Manuel, Pichler, Sabrina, Spaniol, Christian, Glaab, Enrico, Bobbili, Dheeraj Reddy, Antony, Paul, Koegelsberger, Sandra, Kurz, Alexander, Grimmer, Timo, Morgan, Kevin, Vardarajan, Badri N., Reitz, Christiane, Hardy, John, Bras, Jose, Guerreiro, Rita, Balling, Rudi, Schneider, Jochen G., Riemenschneider, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042727/
https://ncbi.nlm.nih.gov/pubmed/29988083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0091-8
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