A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

Lassa virus (LASV) is endemic in Western Africa and is estimated to infect hundreds of thousands of individuals annually. A considerable number of these infections result in Lassa fever (LF), which is associated with significant morbidity and a case-fatality rate as high as 69% among hospitalized co...

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Vydáno v:mBio
Hlavní autoři: Cai, Yingyun, Ye, Chengjin, Cheng, Benson, Nogales, Aitor, Iwasaki, Masaharu, Yu, Shuiqing, Cooper, Kurt, Liu, David X., Hart, Randy, Adams, Ricky, Brady, Tyler, Postnikova, Elena N., Kurtz, Jonathan, St Claire, Marisa, Kuhn, Jens H., de la Torre, Juan Carlos, Martínez-Sobrido, Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042690/
https://ncbi.nlm.nih.gov/pubmed/32098811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00039-20
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