Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats

Mitochondrial autophagy is involved in myocardial protection of sevoflurane postconditioning (SPostC) and in diabetic state this protective effect is weakened due to impaired HIF-1 signaling pathway. Previous studies have proved that deferoxamine (DFO) could activate impaired HIF-1α in diabetic stat...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Yang, Long, Xie, Peng, Wu, Jianjiang, Yu, Jin, Li, Xin, Ma, Haiping, Yu, Tian, Wang, Haiying, Ye, Jianrong, Wang, Jiang, Zheng, Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042377/
https://ncbi.nlm.nih.gov/pubmed/32140105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00006
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