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FK506 regulates Ca(2+) release evoked by inositol 1,4,5‐trisphosphate independently of FK‐binding protein in endothelial cells

BACKGROUND AND PURPOSE: FK506 and rapamycin are modulators of FK‐binding proteins (FKBP) that are used to suppress immune function after organ and hematopoietic stem cell transplantations. The drugs share the unwanted side‐effect of evoking hypertension that is associated with reduced endothelial fu...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Buckley, Charlotte, Wilson, Calum, McCarron, John G.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042112/
https://ncbi.nlm.nih.gov/pubmed/31705533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14905
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