Endothelial TRPV4 channels modulate vascular tone by Ca(2+)‐induced Ca(2+) release at inositol 1,4,5‐trisphosphate receptors

BACKGROUND AND PURPOSE: The TRPV4 ion channels are Ca(2+) permeable, non‐selective cation channels that mediate large, but highly localized, Ca(2+) signals in the endothelium. The mechanisms that permit highly localized Ca(2+) changes to evoke cell‐wide activity are incompletely understood. Here, we...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Heathcote, Helen R., Lee, Matthew D., Zhang, Xun, Saunter, Christopher D., Wilson, Calum, McCarron, John G.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692577/
https://ncbi.nlm.nih.gov/pubmed/31177523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14762
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