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Parameter estimation for sigmoid E(max) models in exposure-response relationship

The purpose of this simulation study is to explore the limitation of the population PK/PD analysis using data from a clinical study and to help to construct an appropriate PK/PD design that enable precise and unbiased estimation of both fixed and random PD parameters in PK/PD analysis under differen...

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Pubblicato in:Transl Clin Pharmacol
Autori principali: Choe, Sangmin, Lee, Donghwan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society for Clinical Pharmacology and Therapeutics 2017
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042008/
https://ncbi.nlm.nih.gov/pubmed/32133323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2017.25.2.74
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