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Population Pharmacodynamic Modeling Using the Sigmoid E(max) Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study
The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathematical models. We investigated the relationship between the steepness of the concentration–effect relationship and inter-individual variability (IIV) of the parameters of the sig...
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| Published in: | AAPS J |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer International Publishing
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7759489/ https://ncbi.nlm.nih.gov/pubmed/33367961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00549-7 |
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