B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient–derived anti-TG2 B cell receptor equally reactive to human and mouse...

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Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: du Pré, M. Fleur, Blazevski, Jana, Dewan, Alisa E., Stamnaes, Jorunn, Kanduri, Chakravarthi, Sandve, Geir Kjetil, Johannesen, Marie K., Lindstad, Christian B., Hnida, Kathrin, Fugger, Lars, Melino, Gerry, Qiao, Shuo-Wang, Sollid, Ludvig M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041703/
https://ncbi.nlm.nih.gov/pubmed/31727780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190860
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