IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers

Activation of Wnt signaling entails βcatenin protein stabilization and translocation to the nucleus to regulate context-specific transcriptional programs. The majority of colorectal cancers (CRCs) initiate following APC mutations, resulting in Wnt ligand—independent stabilization and nuclear accumul...

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Publicado en:J Cell Biol
Autores principales: Mis, Monika, O’Brien, Siobhan, Steinhart, Zachary, Lin, Sichun, Hart, Traver, Moffat, Jason, Angers, Stephane
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2019
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041691/
https://ncbi.nlm.nih.gov/pubmed/31881079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903017
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