Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs

In this study, the mechanism of the anticancer effect through which cucurbitacin D (CuD) can overcome gefitinib resistance in NSCLC was investigated. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assay, and cell migration and growth were observed by woun...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Hong, Se Hyang, Ku, Jin Mo, Lim, Ye Seul, Lee, Seo Yeon, Kim, Ji Hye, Cheon, Chunhoo, Ko, Seong-Gyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041627/
https://ncbi.nlm.nih.gov/pubmed/32133284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00062
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