Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells

Breast cancer is the most common cancer for women and is a major cause of mortality in women. Doxorubicin is a generally used chemotherapy drug for breast cancer. However, multidrug resistance of breast cancer interferes with the chemotherapy. We examined whether cucurbitacin D affects doxorubicin r...

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Veröffentlicht in:Mol Cell Biochem
Hauptverfasser: Ku, Jin Mo, Kim, Soon Re, Hong, Se Hyang, Choi, Han-Seok, Seo, Hye Sook, Shin, Yong Cheol, Ko, Seong-Gyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589559/
https://ncbi.nlm.nih.gov/pubmed/26169986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-015-2509-9
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