Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma

Targeted therapy for kidney cancer has achieved significant clinical results. However, because most patients who use targeted therapy will develop drug resistance, we still need to constantly explore new therapeutic targets. Although porcupine (PORCN) as a palmitoyltransferase plays a crucial role i...

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Pubblicato in:Biomed Res Int
Autori principali: Li, Jianyi, Wu, Guangzhen, Xu, Yingkun, Li, Jiatong, Ruan, Ningke, Chen, Yougen, Zhang, Qi, Xia, Qinghua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040395/
https://ncbi.nlm.nih.gov/pubmed/32104684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2527643
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