A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

Inflammatory joint conditions are characterized by synovial inflammation, which involves activation of fibroblast-like synoviocytes (FLSs) and production of inflammatory mediators and matrix metalloproteases (MMPs) in joints. This study showed that the snake venom metalloprotease (SVMP) BaP1 activat...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Viana, Mariana N., Leiguez, Elbio, Gutiérrez, José M., Rucavado, Alexandra, Markus, Regina P., Marçola, Marina, Teixeira, Catarina, Fernandes, Cristina M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039882/
https://ncbi.nlm.nih.gov/pubmed/32094439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59095-z
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