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A representative metalloprotease induces PGE(2) synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

Inflammatory joint conditions are characterized by synovial inflammation, which involves activation of fibroblast-like synoviocytes (FLSs) and production of inflammatory mediators and matrix metalloproteases (MMPs) in joints. This study showed that the snake venom metalloprotease (SVMP) BaP1 activat...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Viana, Mariana N., Leiguez, Elbio, Gutiérrez, José M., Rucavado, Alexandra, Markus, Regina P., Marçola, Marina, Teixeira, Catarina, Fernandes, Cristina M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039882/
https://ncbi.nlm.nih.gov/pubmed/32094439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59095-z
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