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Discovering the chloride pathway in the CFTR channel

Cystic fibrosis (CF), a lethal monogenic disease, is caused by pathogenic variants of the CFTR chloride channel. The majority of CF mutations affect protein folding and stability leading overall to diminished apical anion conductance of epithelial cells. The recently published cryo-EM structures of...

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Détails bibliographiques
Publié dans:Cell Mol Life Sci
Auteurs principaux: Farkas, Bianka, Tordai, Hedvig, Padányi, Rita, Tordai, Attila, Gera, János, Paragi, Gábor, Hegedűs, Tamás
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039865/
https://ncbi.nlm.nih.gov/pubmed/31327045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03211-4
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