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Discovering the chloride pathway in the CFTR channel
Cystic fibrosis (CF), a lethal monogenic disease, is caused by pathogenic variants of the CFTR chloride channel. The majority of CF mutations affect protein folding and stability leading overall to diminished apical anion conductance of epithelial cells. The recently published cryo-EM structures of...
Enregistré dans:
| Publié dans: | Cell Mol Life Sci |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer International Publishing
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039865/ https://ncbi.nlm.nih.gov/pubmed/31327045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03211-4 |
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