Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway

Multiple observations implicate T-cell dysregulation as a central event in the pathogenesis of rheumatoid arthritis. Here, we investigated mechanisms for suppressing T-cell activation via the inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1). To determine how LAIR-1 af...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Park, Jeoung-Eun, Brand, David D., Rosloniec, Edward F., Yi, Ae-Kyung, Stuart, John M., Kang, Andrew H., Myers, Linda K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039569/
https://ncbi.nlm.nih.gov/pubmed/31932281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011150
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