Peptide Ligand Structure and I-A(q) Binding Avidity Influence T Cell Signaling Pathway Utilization

Factors that drive T cells to signal through differing pathways remain unclear. We have shown that an altered peptide ligand (A9) activates T cells to utilize an alternate signaling pathway which is dependent upon FcRγ and Syk. However, it remains unknown whether the affinity of peptide binding to M...

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Detalhes bibliográficos
Publicado no:Clin Immunol
Main Authors: Myers, Linda K, Cullins, David L, Park, Jeoung-Eun, Yi, Ae-Kyung, Brand, David D, Rosloniec, Edward F, Stuart, John M, Kang, Andrew H
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959786/
https://ncbi.nlm.nih.gov/pubmed/25982319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.05.002
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