Gene expression amplification by nuclear speckle association

Many active genes reproducibly position near nuclear speckles, but the functional significance of this positioning is unknown. Here we show that HSPA1B BAC transgenes and endogenous Hsp70 genes turn on 2–4 min after heat shock (HS), irrespective of their distance to speckles. However, both total HSP...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Kim, Jiah, Venkata, Neha Chivukula, Hernandez Gonzalez, Gabriela Andrea, Khanna, Nimish, Belmont, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039209/
https://ncbi.nlm.nih.gov/pubmed/31757787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201904046
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