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Evolutionarily conserved and divergent regions of the Autoimmune Regulator (Aire) gene: a comparative analysis
During T cell differentiation, medullary thymic epithelial cells (MTEC) expose developing T cells to tissue-specific antigens. MTEC expression of such self-antigens requires the transcription factor autoimmune regulator (Aire). In mammals, defects in aire result in multi-tissue, T cell-mediated auto...
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| Gepubliceerd in: | Immunogenetics |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039057/ https://ncbi.nlm.nih.gov/pubmed/18214467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-007-0268-9 |
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