The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

7-Methylguanosine 5′ cap on mRNA is necessary for efficient protein expression in vitro and in vivo. Recent studies revealed structural diversity of endogenous mRNA caps, which carry different 5′-terminal nucleotides and additional methylations (2′-O-methylation and m(6)A). Currently available 5′-ca...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Sikorski, Pawel J, Warminski, Marcin, Kubacka, Dorota, Ratajczak, Tomasz, Nowis, Dominika, Kowalska, Joanna, Jemielity, Jacek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
NAR Breakthrough Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038993/
https://ncbi.nlm.nih.gov/pubmed/31984425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa032
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