Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells

UVA-induced mutagenesis was investigated in human pol eta-deficient (XP-V) cells through whole-exome sequencing. In UVA-irradiated cells, the increase in the mutation frequency in deficient cells included a remarkable contribution of C>T transitions, mainly at potential pyrimidine dimer sites. A...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Moreno, Natália Cestari, de Souza, Tiago Antonio, Garcia, Camila Carrião Machado, Ruiz, Nathalia Quintero, Corradi, Camila, Castro, Ligia Pereira, Munford, Veridiana, Ienne, Susan, Alexandrov, Ludmil B, Menck, Carlos Frederico Martins
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038989/
https://ncbi.nlm.nih.gov/pubmed/31853541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1182
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