Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to β-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model

Supplementation of standard growth media (cation-adjusted Mueller-Hinton Broth [CAMHB]) with bicarbonate (NaHCO(3)) increases β-lactam susceptibility of selected methicillin-resistant Staphylococcus aureus (MRSA) strains (“NaHCO(3) responsive”). This “sensitization” phenomenon translated to enhanced...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Rose, Warren E., Bienvenida, Ana M., Xiong, Yan Q., Chambers, Henry F., Bayer, Arnold S., Ersoy, Selvi C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038310/
https://ncbi.nlm.nih.gov/pubmed/31844004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02072-19
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