Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against Enterobacteriaceae

Benapenem is a novel carbapenem. The objective of this study was to determine the pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal administration regimens of benapenem for the treatment of bacterial infections via PK/PD modeling and simulation. Ertapenem was used as a...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Ji, Xi-wei, Xue, Feng, Kang, Zi-sheng, Zhong, Wei, Kuan, Isabelle Hui-san, Yang, Xi-ping, Zhu, Xiao, Li, Yun, Lv, Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038265/
https://ncbi.nlm.nih.gov/pubmed/31844001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01751-19
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