Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients

Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug monitoring. Germline mutations in cytochrome P450 isoforms 4 and 5 genes (CYP3A4/5) and the ATP-binding cassette B1 gene (ABCB1) may contribute to...

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Publicado no:Int J Mol Sci
Main Authors: Zhu, Jing, Patel, Tejendra, Miller, Jordan A., Torrice, Chad D., Aggarwal, Mehak, Sketch, Margaret R., Alexander, Maurice D., Armistead, Paul M., Coghill, James M., Grgic, Tatjana, Jamieson, Katarzyna J., Ptachcinski, Jonathan R., Riches, Marcie L., Serody, Jonathan S., Schmitz, John L., Shaw, J. Ryan, Shea, Thomas C., Suzuki, Oscar, Vincent, Benjamin G., Wood, William A., Rao, Kamakshi V., Wiltshire, Tim, Weimer, Eric T., Crona, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037631/
https://ncbi.nlm.nih.gov/pubmed/32013193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030858
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