Analysis of NFATc1 amplification in T cells for pharmacodynamic monitoring of tacrolimus in kidney transplant recipients

BACKGROUND: Therapeutic drug monitoring (TDM) of tacrolimus, based on blood concentrations, shows an imperfect correlation with the occurrence of rejection. Here, we tested whether measuring NFATc1 amplification, a member of the calcineurin pathway, is suitable for TDM of tacrolimus. MATERIALS AND M...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kannegieter, Nynke M., Hesselink, Dennis A., Dieterich, Marjolein, de Graav, Gretchen N., Kraaijeveld, Rens, Baan, Carla C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056039/
https://ncbi.nlm.nih.gov/pubmed/30036394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201113
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