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Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis

ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in the defense of cells and tissues against cytotoxic chemicals, but these transporters can also confer chemotherapy resistance states in oncology. Understanding the mechanism of ABCG2 is thu...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Principais autores: Kapoor, Parth, Briggs, Deborah A., Cox, Megan H., Kerr, Ian D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037313/
https://ncbi.nlm.nih.gov/pubmed/31979415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030759
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