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Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from a number of organs in the body. The trafficking of the protein and the mechanism by which it recognizes and transports diverse drugs are impo...

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Bibliografski detalji
Izdano u:Biosci Rep
Glavni autori: Haider, Ameena J., Cox, Megan H., Jones, Natalie, Goode, Alice J., Bridge, Katherine S., Wong, Kelvin, Briggs, Deborah, Kerr, Ian D.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613716/
https://ncbi.nlm.nih.gov/pubmed/26294421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150150
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