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Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration
The maintenance of proper cytosolic Ca(2+) level is crucial for neuronal survival, and dysregulation of Ca(2+) homeostasis is found in a variety of neurological disorders, including Alzheimer’s disease. According to the “Ca(2+) hypothesis of aging”, Ca(2+) disturbances precede the onset of AD sympto...
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| Veröffentlicht in: | Int J Mol Sci |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7037127/ https://ncbi.nlm.nih.gov/pubmed/32012922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030842 |
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