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Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies
Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD(+)-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described the discovery of a dual SIRT1/SIRT2 inhibitor called cambinol (IC(50) 56 and 59 µM,...
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| Veröffentlicht in: | Molecules |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7036909/ https://ncbi.nlm.nih.gov/pubmed/31973227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25030455 |
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