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Regulation of DGKε Activity and Substrate Acyl Chain Specificity by Negatively Charged Phospholipids

Diacylglycerol kinase ε (DGKε) is a membrane-bound enzyme that catalyzes the ATP-dependent phosphorylation of diacylglycerol to form phosphatidic acid (PA) in the phosphatidylinositol cycle. DGKε lacks a putative regulatory domain and has recently been reported to be regulated by highly curved membr...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Bozelli, José Carlos, Yune, Jenny, Hou, You H., Chatha, Preet, Fernandes, Alexia, Cao, Zihao, Tong, Yufeng, Epand, Richard M.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036746/
https://ncbi.nlm.nih.gov/pubmed/31587830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.09.008
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