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The Long Road to the First FDA Approved Gene Therapy: Chimeric Antigen Receptor T Cells Targeting CD19

Thirty years after initial publications of the concept of a chimeric antigen receptor (CAR), the U.S. Food and Drug Administration (FDA) approved the first anti-CD19 CAR T cell therapy. Unlike other immunotherapies such as immune checkpoint inhibitors and bispecific antibodies, CAR T cells are uniqu...

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Publicat a:Cytotherapy
Autors principals: Braendstrup, Peter, Levine, Bruce L., Ruella, Marco
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036015/
https://ncbi.nlm.nih.gov/pubmed/32014447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2019.12.004
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