Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1

Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pathway through an unknown mechanism. Herein, we ident...

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Publicado no:Mol Cell
Main Authors: Najt, Charles P., Khan, Salmaan A., Heden, Timothy D., Witthuhn, Bruce A., Perez, Minervo, Heier, Jason L., Mead, Linnea E., Franklin, Mallory P., Karanja, Kenneth K., Graham, Mark J., Mashek, Mara T., Bernlohr, David A., Parker, Laurie, Chow, Lisa S., Mashek, Douglas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036014/
https://ncbi.nlm.nih.gov/pubmed/31901447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.12.003
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