Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

β-amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological hallmarks of Alzheimer’s disease (AD) and are thought to play crucial roles in a neurodegenerative cascade leading to dementia. Both lesions can now be visualized in vivo using positron emission tomography (PE...

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Publicado en:Sci Transl Med
Main Authors: La Joie, Renaud, Visani, Adrienne V., Baker, Suzanne L., Brown, Jesse A., Bourakova, Viktoriya, Cha, Jungho, Chaudhary, Kiran, Edwards, Lauren, Iaccarino, Leonardo, Janabi, Mustafa, Lesman-Segev, Orit, Miller, Zachary, Perry, David C., O’Neil, James P., Pham, Julie, Rojas, Julio C., Rosen, Howard J., Seeley, William W., Tsai, Richard M., Miller, Bruce L., Jagust, William J., Rabinovici, Gil D.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035952/
https://ncbi.nlm.nih.gov/pubmed/31894103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau5732
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