Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET

OBJECTIVE: To assess whether Alzheimer disease (AD) clinical presentation and APOE4 relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET imaging. METHODS: We studied 119 Aβ-positive symptomatic patients aged 48–95 years, including 29 patients with logopenic var...

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Udgivet i:Neurology
Main Authors: La Joie, Renaud, Visani, Adrienne V., Lesman-Segev, Orit H., Baker, Suzanne L., Edwards, Lauren, Iaccarino, Leonardo, Soleimani-Meigooni, David N., Mellinger, Taylor, Janabi, Mustafa, Miller, Zachary A., Perry, David C., Pham, Julie, Strom, Amelia, Gorno-Tempini, Maria Luisa, Rosen, Howard J., Miller, Bruce L., Jagust, William J., Rabinovici, Gil D.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884991/
https://ncbi.nlm.nih.gov/pubmed/33262228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000011270
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