CAR, a Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil

Here, we sought to elucidate the role of CAR (a cyclic peptide) in the accumulation and distribution of fasudil, a drug for pulmonary arterial hypertension (PAH), in rat lungs and in producing pulmonary specific vasodilation in PAH rats. As such, we prepared liposomes of fasudil and CAR-conjugated l...

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Vydáno v:Mol Pharm
Hlavní autoři: Keshavarz, Ali, Alobaida, Ahmed, McMurtry, Ivan F., Nozik-Grayck, Eva, Stenmark, Kurt R., Ahsan, Fakhrul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035787/
https://ncbi.nlm.nih.gov/pubmed/31194563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00208
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