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T-13 and T-26, the novel taxanes with improved oral bioavailability in rats

In an attempt to improve the oral bioavailability of taxanes, a series of new analogues were synthesized and tested in a panel of human tumor cell lines and cellular permeability assays. Compounds T-13 and T-26 showed potent cytotoxicity and exhibited the highest permeability, so they were selected...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Jing, Yun-Rong, Zhou, Wei, Wang, Xiang-Yang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035259/
https://ncbi.nlm.nih.gov/pubmed/32081942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60184-2
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