Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

RATIONALE: Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondrial deacetylase Sirt3 is critical in the regu...

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Publicado en:Circ Res
Main Authors: Dikalova, Anna E., Pandey, Arvind, Xiao, Liang, Arslanbaeva, Liaisan, Sidorova, Tatiana, Lopez, Marcos G., Billings, Frederic T., Verdin, Eric, Auwerx, Johan, Harrison, David G., Dikalov, Sergey I.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035170/
https://ncbi.nlm.nih.gov/pubmed/31852393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315767
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