Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension

RATIONALE: Clinical studies have shown that Sirt3 expression declines by 40% by age 65 paralleling the increased incidence of hypertension and metabolic conditions further inactivate Sirt3 due to increased NADH and acetyl-CoA levels. Sirt3 impairment reduces the activity of a key mitochondrial antio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Circ Res
Prif Awduron: Dikalova, Anna E., Itani, Hana A., Nazarewicz, Rafal R., McMaster, William G., Flynn, Charles R., Uzhachenko, Roman, Fessel, Joshua P., Gamboa, Jorge L., Harrison, David G., Dikalov, Sergey I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562527/
https://ncbi.nlm.nih.gov/pubmed/28684630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.310933
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