Circulating Uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

High serum concentrations of kidney-derived protein uromodulin (Tamm-Horsfall protein or THP) have recently been shown to be independently associated with low mortality in both older adults and cardiac patients, but the underlying mechanism remains unclear. Here, we show that THP inhibits the genera...

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Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: LaFavers, Kaice A., Macedo, Etienne, Garimella, Pranav S., Lima, Camila, Khan, Shehnaz, Myslinski, Jered, McClintick, Jeanette, Witzmann, Frank A., Winfree, Seth, Phillips, Carrie, Hato, Takashi, Dagher, Pierre, Wu, Xue-Ru, El-Achkar, Tarek M., Micanovic, Radmila
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034444/
https://ncbi.nlm.nih.gov/pubmed/31578243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw3639
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