Circulating Uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

High serum concentrations of kidney-derived protein uromodulin (Tamm-Horsfall protein or THP) have recently been shown to be independently associated with low mortality in both older adults and cardiac patients, but the underlying mechanism remains unclear. Here, we show that THP inhibits the genera...

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Vydáno v:Sci Transl Med
Hlavní autoři: LaFavers, Kaice A., Macedo, Etienne, Garimella, Pranav S., Lima, Camila, Khan, Shehnaz, Myslinski, Jered, McClintick, Jeanette, Witzmann, Frank A., Winfree, Seth, Phillips, Carrie, Hato, Takashi, Dagher, Pierre, Wu, Xue-Ru, El-Achkar, Tarek M., Micanovic, Radmila
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034444/
https://ncbi.nlm.nih.gov/pubmed/31578243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw3639
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