CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions

DNA damage response (DDR) is critically important for cell survival, genome maintenance, and its defect has been exploited therapeutically in cancer treatment. Many DDR-targeting agents have been generated and have entered the clinic and/or clinical trials. In order to provide a global and unbiased...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Su, Dan, Feng, Xu, Colic, Medina, Wang, Yunfei, Zhang, Chunchao, Wang, Chao, Tang, Mengfan, Hart, Traver, Chen, Junjie
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034363/
https://ncbi.nlm.nih.gov/pubmed/31991288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102803
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