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Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects. Sustained release THCl nanosponges hydrogel was fabricated to deliver the drug topically. Pure THCl (d...

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Bibliografiske detaljer
Udgivet i:J Adv Pharm Technol Res
Main Authors: Amer, Reham I., El-Osaily, Ghada H., Gad, Sameh S.
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer - Medknow 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034181/
https://ncbi.nlm.nih.gov/pubmed/32154153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/japtr.JAPTR_85_19
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