Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy

BACKGROUND: Trypanosoma cruzi is an intracellular parasite that causes debilitating chronic Chagas cardiomyopathy (CCM), for which there is no effective drug or vaccine. Previously, we demonstrated increased cardiac lipid accumulation and endoplasmic reticulum stress in mice with CCM. Increased endo...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Ayyappan, Janeesh Plakkal, Lizardo, Kezia, Wang, Sean, Yurkow, Edward, Nagajyothi, Jyothi F.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033903/
https://ncbi.nlm.nih.gov/pubmed/31973605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.014255
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