Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily formed by pancreatic stellate cells (PSCs). The effects of the altered biomechanics and pH landscape in the pathogenesis of PDAC, however, are p...

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Bibliografske podrobnosti
izdano v:Front Physiol
Main Authors: Kuntze, Anna, Goetsch, Ole, Fels, Benedikt, Najder, Karolina, Unger, Andreas, Wilhelmi, Marianne, Sargin, Sarah, Schimmelpfennig, Sandra, Neumann, Ilka, Schwab, Albrecht, Pethő, Zoltan
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Physiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033545/
https://ncbi.nlm.nih.gov/pubmed/32116794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00089
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