Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily formed by pancreatic stellate cells (PSCs). The effects of the altered biomechanics and pH landscape in the pathogenesis of PDAC, however, are p...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Kuntze, Anna, Goetsch, Ole, Fels, Benedikt, Najder, Karolina, Unger, Andreas, Wilhelmi, Marianne, Sargin, Sarah, Schimmelpfennig, Sandra, Neumann, Ilka, Schwab, Albrecht, Pethő, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033545/
https://ncbi.nlm.nih.gov/pubmed/32116794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00089
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