Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and ventilator-induced lung injury (VILI). Autophagy is a key regulator of inflammasome activation in macrophages. Here, we investigated the role of autopha...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Nosaka, Nobuyuki, Martinon, Daisy, Moreira, Debbie, Crother, Timothy R., Arditi, Moshe, Shimada, Kenichi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033480/
https://ncbi.nlm.nih.gov/pubmed/32117318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00207
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